Description

Cough Free Performance with Alert Daily Activities

On-Cof Free from Sedation & hazards of conventional cough syrups.
On-Cof Ensures Efficacy as Bronchodilator and Expectorant.
On-Cof Ensures soothing effect in all types of cough.
On-Cof Ensures alert daily activities.
On-Cof Can be safely used in both children & adults.
On-Cof Can safely use in diabetic patients.

Indication:

On-Cof is beneficial to both productive and dry cough. The mucolytic & expectorant properties reduce the viscosity of bronchial secretions & facilitate expectoration.

On-Cof peripheral antitussive action irritation and related the bronchial mucosal addition, the anti-allergic, anti inflammatory and immune modifying properties provide relief from cough.

• Congestion,
• Cough,
• Hoarseness,
• Sore Throat,
• Help loosen phlegm (mucus) to make coughs more productive.

Ivy Leaf (Hedera Helix) Expectorant & Bronchodilator: EMEA recommends Ivy Leaf based Syrups as highly Effective & Safe. Ivy Leaf based preparations are being used & trusted worldwide. EMEA2010.

Licorice (Glycyrrhiza glabra) Expectorant & Demulcent: The antitussive and expectorant properties of Glycyrrhiza glabra have been attributed to Glycyrrhizin which accelerates tracheal mucus secretion.WHO Monograph.

Bryonia Alba & Aconitum napellus: According to Multicenter study, 93.5% improvement in the intensity of coughing was observed in patients. EMEA 2010.

Active Ingredient                      Purpose

Ivy Leaf Extract                                     Soother a dry & irritated respiratory systems, relaxing the airways.

Glycyrrhiza Glabra (Liquorice)          Cough Suppressant Pain reliever for the throat.
Hepar sulphuris calcareum                Cough Suppressant.
Bryonia Alba

Aconitum napellus                                 Cough Suppressant & Pain reliever

Dosage:

Below 5 Years: 2.5ml 3 times daily.
6-12 Years: 5ml 3 times daily.
Above 12 Years and adults: 5ml to 7.5ml 3 times daily or as directed by physician.

Hazards Conventional Cough Syrups

AAP Recommendations against the use of Dextromethorphan & Codeine
According to AAP (American Academy of Pediatrics) use of DXM & Codeine may cause significant morbidity & mortality especially in young children.

Conventional Cough Syrups May Cause Serious Side Effects

Ingredients                         Action / Status                         Side Effects                              Safety Profile

Ephedrine………………………..CNS Stimulant/…………………….Hypertension……………………..Not safe for Cardiac/
………………………………………… FDA Banned OTC use………….Arrhythmia…………………………Hypertensive patients
…………………………………………………………………………………………Nervousness

Chlorpheniramine…………..Anti histamines work…………Drowsiness                               Should be used with
Diphenhydramine…………..due to sedative &…………………Severe Sedation…………………..caution especially in
Promethazine………………….anticholinergic action…………………………………………………………children.
………………………………………….They have been promo-
………………………………………….ted for treatment of
………………………………………….cough in allergic states.

Codeine…………………………….Blocks Cough Center……………Sedations, nausea,…………………Contraindicated in
………………………………………….in Medulla…………………………….constipation at……………………….asthmatic patients
…………………………………………………………………………………………..higher doses
…………………………………………………………………………………………..respiratory depression
…………………………………………………………………………………………..& drowsiness can occur

Dextromethorphan………..Controls cough by……………….Toxic doses may cause……….Contraindicated in
…………………………………………depressing cough………………stupor, ataxia, respiratory       children below 6 yrs
…………………………………………center in medulla………………depression, convulsion            of age and also in
…………………………………………& Increase the……………………in children and death              patients taking
…………………………………………threshold for coughing……..with abuse of its purified        Monoamine oxidase
…………………………………………powder.………………………………inhibitors.

Guaiphenesin………………….Decrease sputum……………….Nausea, gastric………………………Avoid use in
…………………………………………viscosity & increase…………..disturbances…………………………..sensitive patients.
…………………………………………sputum volume…………………drowsiness & rash

Bromhexine…………………It depolymerizes the…………….Rhinorrhoea,…………………………..Runny Nose
………………………………………polysaccharides……………………lacrimation, &…………………………is itself very
………………………………………in mucous plugs……………………gastric irritation……………………..disturbing.